辛伐他汀对尿毒症非透析患者血清白介素-6、C反应蛋白和营养学指标的影响

Influence of simavastatin on interleukin-6,C-reactive protein and nutrition indicators in uremia patients without dialysis

目的探讨辛伐他汀治疗对尿毒症非透析患者微炎症反应和营养学指标的影响。方法选择湖本院肾内科尿毒症非透析患者86例,随机分为他汀治疗组和对照组,监测治疗前、治疗后C反应蛋白(CRP)、白细胞介素-6(IL-6)和基础营养状态指标的变化。结果与正常人组比较,治疗前尿毒症患者的CRP、IL-6水平显著升高,血浆白蛋白(ALB)、血红蛋白(Hb)均显著降低。治疗后24周,他汀治疗组CRP、IL-6、血肌酐(Scr)、尿素氮(BUN)水平均明显下降,Alb、Hb水平明显升高,与治疗前及对照组相比,差异有统计学意义:同时对照组Alb、Hb、Ccr也呈下降趋势,2组肌酐清除率(Cer)变化无显著性。结论辛伐他汀治疗可以抑制尿毒症非透析患者的微炎症反应,改善营养状态。

Objective To investigate the influence of simavastatin on microinflammation and nutrition indicators in uremia patients without dialysis.Methods Eighty-six uremia patients witout dialysis from our hospital were randomly divided into statin treatment group and control group.The changes of C-reactive protein（CRP）,interleukin-6（IL-6） and nutrition indicators were monitored before and after treatment.Results Compared with the control group,the levels of CRP and IL-6 of the statin treatment group were significantly increased,while plasma albumin（ALB） and hemoglobin（Hb） were significantly decreased.24 weeks after treatment,the levels of CRP,IL-6,serum creatinine（Scr） and blood urea nitrogen（BUN） of the statin treatment group were significantly decreased,while the levels of Alb and Hb were significantly increased.Compared with the pre-treatment and control group,the difference was statistically significant.Meanwhile Alb,Hb and Ccr in the control group showed a downward trend.There were no significant changes in the two groups in terms of creatinine clearance.Conclusion Simvastatin treatment can inhibit the micro-inflammatory response of the uremic non-dialysis and improve nutritional status.