摘要
目的系统评价美洛昔康用于紧急避孕的有效性和安全性。方法全面检索相关文献,对根据纳入标准筛选后的研究进行严格评价和Meta分析。结果最终纳入3个随机对照试验,Meta分析结果显示,美洛昔康可增大主导卵泡直径可延迟女性排卵时间;试验组和对照组的不良反应发生率比较,差异无统计学意义;美洛昔康30 mg/d的避孕效果优于15 mg/d。结论美洛昔康30 mg/d用于紧急避孕有效且相对安全。但该系统评价纳入的研究样本量较小,现有证据尚不足以推荐此方案广泛用于避孕,还需开展更多大样本随机双盲对照试验加以验证。
Objective To evaluate the effectiveness and safety of meloxicam in emergency contraception. Methods By retrieving all rela- tive literature and screening the researches according to the inclusion criteria,the included researches were performed the strict evalua- tion and Meta analysis. Results 3 randomized controlled trials（RCTs） were included. The meta- analysis Results showed that meloxicam could enlarge the diameter of dominant follicle and delay the female ovulation time. There was no statistically significant difference in the incidence of adverse reactions between the trial group and control group. Meloxicam 30 mg/d was more effective than 15 mg/d. Conclusion Meloxicam 30 mg/d is effective and relatively safe for emergency contraception. However,due to smaller included sample size, the existing evidences are insufficient to recommend this regimen widely used in crowd requiring contraception. Therefore more ran- domized double- blind controlled trials with large sample are required for further verification.
出处
《中国药业》
CAS
2012年第18期26-28,共3页
China Pharmaceuticals
关键词
美洛昔康
紧急避孕
系统评价
META分析
meloxicam
emergency contraception
systematic evaluation
Meta - analysis
