摘要
目的:以氯氮平为对照,探讨阿立哌唑治疗老年精神分裂症的疗效与安全性。方法:对123例老年精神分裂症患者随机分成两组,研究组61例,对照组62例,于治疗前和治疗后1、2、4、6、8周末进行PANSS评分和TESS评价疗效。结果:阿立哌唑治疗老年精神分裂症与氯氮平无显著差异;在认知因子和阴性症状方面,二者差异显著。结论:阿立哌唑是一种安全、有效的非典型抗精神病药物。
Objective ： To determine the efficacy and safety of Aripiprazole in the treatment of schizophrenia by using Clozapine as a control. Methods ：60 cases with schizophrenia were randomly divided into Aripiprazole and controlled （Clozapine） groups. The first group had 61 cases, the other group had 63 cases. PANSS and TESS scales were used to measure effectiveness and safety before treatment and at the end of week 1,2,4,6 and 8, respectively. Results： There were no significant different in effectiveness between two groups. However significant differences were found between two groups in the score reduce rates about cognitive factors and negative symptoms. Conclusions： The study suggests that Aripiprazole is a safe and effective agent in the treatment of schizophrenia.
出处
《中国民康医学》
2012年第17期2057-2059,共3页
Medical Journal of Chinese People’s Health
