短暂性脑缺血发作后脑梗死与纤维蛋白原水平和颈动脉粥样硬化的关系研究

The Relationships of Thecarotid Atherosclerosis and the Level of Fibrinogen in Patients with Cerebral Infarction after Transient Ischemic Attack

目的探讨短暂性脑缺血发作(TIA)患者脑梗死的发生与纤维蛋白原水平及颈动脉斑块、颈动脉狭窄的关系。方法对80例TIA患者进行2周临床观察,分成梗死组17例和稳定组63例,测定纤维蛋白原水平,进行颈动脉多普勒超声检查。结果 80例患者中17例发生脑梗死,脑梗死发生率为21.25%;梗死组纤维蛋白原水平显著高于稳定组,差异有统计学意义(P<0.05);颈动脉超声检查发现梗死组患者颈动脉易损斑块14例(82.3%),稳定组26例(41.3%),两组比较,差异有统计学意义(P<0.01);梗死组颈内动脉狭窄8例(47.1%),稳定组8例(12.7%),两组比较,差异有统计学意义(P<0.01)。结论纤维蛋白原水平以及颈动脉粥样硬化程度与TIA后脑梗死的发生有相关,可作为TIA近期发生脑梗死风险的预测指标。

Objective To investigate the relationships of the level of fibrinogen,and carotid artery plaque,and carotid stenosis in patients with cerebral infarction after transient ischemic attack.Methods After two weeks of clinical observation,80 patients with TIA were falled into infarction group 17 cases and stable group 63 cases.The level of fibrinogen was detectioned and carotid doppler ultrasound was assessed.Results In 80 patients,17 cases occured cerebral infarction,the incidence of cerebral infarction was 21.25%;The level of fibrinogen in the infarction group was higher than in the stable group,the difference was statistically significant（P〈0.05）;Of carotid ultrasound examination,vulnerable plaque was revealed in 14 cases（82.3%）of the infarction group,26 cases（41.3%）of the stable group,the difference was statistically significant（P〈0.01）;The internal carotid artery stenosis was revealed in 8 cases（47.1%） of the infarction group,8 cases（12.7%）of the stable group,the difference was statistically significant（P〈0.01）.Conclusion The occurrence of cerebral infarction after TIA is Related with the level of fibrinogen and carotid atherosclerosis extent,that can be predictors of the recent cases of cerebral infarction risk in patients with TIA.