摘要
2型糖尿病的发病机制主要涉及胰岛素抵抗和胰岛素分泌缺乏。研究表明，胰高血糖素样肽一1受体激动剂在有效改善胰岛p细胞功能，促进胰岛素分泌的同时，还能够作用于细胞信号转导，促进脂肪细胞分化和葡萄糖摄取，并通过减轻相关炎性反应因子表达，降低体重等，改善胰岛素抵抗，增加胰岛素敏感性。
Insulin resistance and lack of insulin secretion is the main pathogenesis of type 2 diabe- tes. Researches have shown that glucagon-like peptide-1 （ GLP-I ） receptor agonists could effectively improve the function of pancreatic [3 cell, and promote the secretion of insulin. Moreover, GLP-1 receptor agonists could regulate signal transduction,increase adipocytes differentiation and gXucose uptake, decrease expression of inflammation factors, reduce weight and so on. Therefore, it can improve insulin resistance,increase insulin sensitivity
出处
《国际内分泌代谢杂志》
北大核心
2012年第5期318-320,共3页
International Journal of Endocrinology and Metabolism
关键词
胰高血糖素样肽-1
信号转导
脂肪细胞分化
葡萄糖摄取
炎症
Glucagon-like peptide-1
Signal transduction
Adipocyte differentiation
Glucose up- take
lntlammation
