SAMP10痴呆小鼠持续的甲亢体征与痴呆的关系

Relationship between continuous signs of hyperthyroidism and dementia in SAMP10 mice

目的检测SAMP10小鼠中是否存在甲亢体征,探讨持续的甲亢体征在痴呆发生过程中可能的作用。方法选取2月龄和8月龄SAMP10小鼠和SAMR1小鼠各20只,采用电化学发光方法检测小鼠血清TSH、T3、T4、FT3、FT4水平,采用大生化仪检测血脂水平,利用Morris水迷宫方法检测SAMP10小鼠学习记忆能力。结果自2月龄开始,SAMP10小鼠的血胆固醇水平显著低于SAMR1小鼠,血清FT3水平显著高于SAMR1小鼠;在8月龄时,SAMP10小鼠体质量和学习记忆能力较SAMR1小鼠明显降低。结论 SAMP10小鼠自2月龄就持续存在甲亢体征,8月龄时出现明显痴呆状况,SAMP10小鼠持续的甲亢可能在其伴老化的痴呆进程中起重要作用。

Objective It is to detect wether signs of hyperthyroidism exist in SAMP10 mice, and to explore its roles in the development of dementia. Methods 20 cases of 1 and 8 months old SAMPIO mice and SAMR1 mice were chosen respectively. The levels of TSH, T3 , T4 , FT3 , FT4 in serum of the mice were detected using electric-chemical detective system, and the blood fat level was determined by big biochemistry analyzer, the memory and learning ability of SAMP10 mice were detected by Morris Water Maze Test. Results The blood cholesterol level was obviously lower and the serum FT3 level was higher than that of SAMR1 mice from 2 months age ; at 8 months age, the weight and the memory ability of SAMPIO mice were lower than that of SAMR1 mice. Conclusion There are continued hyperthyroidism symptoms from 2 months age and obvious dementia at 8 months age in SAMP10 mice. These results suggest that hyperthyroidism maybe play a critical role in the development of dementia in SAMP10 mice.