新型喜树碱类衍生物9-甲基哌嗪甲基-10-羟基喜树碱氮氧化物对肺癌A549细胞缺氧诱导因子-1α表达的影响被引量：1

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摘要前期实验已证实9-甲基哌嗪甲基-10-羟基喜树碱氮氧化物（HCNO—YCS-03）在体内外均有较好的抑瘤活性，并具有乏氧选择性，是一种新型靶向乏氧微环境的喜树碱类药物。研究结果显示喜树碱类衍生物可通过与拓扑异构酶I有关的全新信号通路抑制缺氧诱导因子（HIF）-1的表达和功能。

作者徐益文徐庆祥李玉艳王磊丁义涛

机构地区常州市第四人民医院普外科鼓楼医院肝胆外科中国药科大学药化教研室

出处《中华实验外科杂志》 CAS CSCD 北大核心 2012年第9期1859-1860,共2页 Chinese Journal of Experimental Surgery

基金国家自然科学基金青年基金资助项目（81102317）江苏省自然科学基金项目（BK2007004）

关键词缺氧诱导因子-1Α 10-羟基喜树碱喜树碱类衍生物肺癌A549细胞氮氧化物哌嗪喜树碱类药物拓扑异构酶I

参考文献8

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1胡赞,李敏,胡成平,莫贵艳,顾其华.缺氧环境下A549细胞促进人脐静脉内皮细胞迁移及血管形成[J].中国呼吸与危重监护杂志,2014,13(2):179-184.

中华实验外科杂志

2012年第9期

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