MicroRNA与垂体腺瘤关系的研究进展

The Progress of the Relationship between microRNA and Pituitary Adenoma

MicroRNA(miRNA)是新发现的一类特殊的小分子RNA,在基因的转录后调控中扮演重要的角色。研究发现很多良恶性肿瘤在发生发展过程中都伴有miRNA的异常表达,所以miRNA的转录后调控机制以及在肿瘤成瘤过程中的作用逐渐成为当下研究的热点,本文就目前垂体腺瘤与miRNA的研究现状做以简要概述。

MicroRNAs （miRNAs） are small RNA molecules that play a crucial role as post- transcriptional regulators of gene expression. There is conclusive evidence that altered miRNA expression and subsequent gene regulation in normal tissues may lead to cancer development. In the pituitary, research has built fundamental connections between aberrant miRNA expression and neoplasia, var- ious findings demonstrate the immense fiznetional range of miRNA as regulators of gene expression in the pituitary. This review will as- sess the significance of miRNAs in pituitary pathology.