细胞因子和脂肪细胞因子在非酒精性脂肪肝中研究新进展

Novel Insights into the Cytokines and Adipocytokines of Non-alcoholic Fatty Liver Disease

非酒精性脂肪性肝病(Non-alcoholic fatty liver disease,NAFLD)是遗传-环境-代谢应激相关因素所致的以肝细胞脂肪变性为主的临床病理综合征,其发生、发展均与细胞因子及脂肪细胞因子密切相关。本文回顾了肿瘤坏死因子-α(Tumornecrosisfactor-α,TNF-α)、白介素-6(interleukin-6,IL-6)、脂联素等经典因子与NAFLD的关系研究新进展,并介绍了视黄醇结合蛋白4(retinolbinding protein4,RBP4)、apelin、visfatin等新脂肪细胞因子在NAFLD中的作用。

Non-alcoholic fatty liver disease （NAFLD）is a group of genetic-environment- metabolic clinical syndrome mainly caused by hepatic steatosis. The development of NAFLD is closely related with various cytokines and adipocytokines. This article reviewed the pivotal role of cytokines such as TNF-α, IL-6 and adiponectin in the pathological progress of NAFLD, and new adipocytokines Retinol Binding Protein 4（RBP4）; apelin and visfatin were also included in the review.