血清sLOX-1水平与子痫前期发病的相关性研究

Study on the correlation between serum sLOX-1 level and onset of preeclampsia

目的:评价血清可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)水平与子痫前期发病相关性。方法:该横断面研究共纳入子痫前期孕妇93例,其中轻度子痫前期孕妇45例,重度子痫前期孕妇48例。选取同期正常妊娠妇女40例为对照组,采用酶联免疫吸附法(ELISA)检测各组血清sLOX-1水平。结果:子痫组患者血清sLOX-1水平显著高于正常对照者(P<0.01);而重度子痫前期组血清sLOX-1水平显著高于轻度子痫前期组(P<0.05)。多元Logistic回归分析显示,血清sLOX-1水平是子痫前期发病的独立危险因子(P<0.01)。结论:血清sLOX-1水平与子痫前期发病独立相关并随着病情的加重而增加,sLOX-1可能成为预测子痫前期发病的重要的血清学生物标记物。

Objective： To evaluate the correlation between serum soluble lectin -like oxidized low -density lipoprotein receptor- 1 （ sLOX - 1 ） level and onset of preeclampsia. Methods ： A total of 93 pregnant women with preeclampsia were included in the cross - sectional study, including 45 pregnant women with mild preeclampsia and 48 pregnant women with severe preeclampsia. Forty normal pregnant women during the same period were selected as control group. ELISA was used to detect the levels of serum sLOX - 1 in different groups. Results ： The level of serum sLOX - 1 in preeclampsia group was statistically significantly higher than that in control group （ P 〈 0.01 ）, while the level of serum sLOX - 1 in severe preeclampsia group was statistically significantly higher than that in mild preeclampsia group （P 〈 0. 05） . Multivariate logistic regression analysis showed that serum sLOX - 1 level was the independent risk factor of onset of preeclampsia （P 〈 0.01 ） . Conclusion： Serum sLOX 1 level is independently correlated with onset of preeclampsia, which increases with aggravation of the disease, sLOX - 1 might be an important serological biomarker for predicting onset of preeclampsia.