宫颈上皮内瘤变LEEP治疗前后HPV16/18的变化及其意义

Change and significance of HPV 16/18 in cervical intraepithelial neoplasia before and after LEEP

目的:探讨宫颈上皮内瘤变LEEP治疗前后HPV16/18的变化及其意义。方法:对通过宫颈活组织病理和阴道镜检查诊断为CIN并接受LEEP术治疗的200例患者检测在LEEP手术前及手术后6、18个月的HPV16/18水平。结果:LEEP术前CINI、CINⅡ、CINⅢ宫颈组织HPV16/18阳性率分别为42.0%、63.6%、81.8%,术后6个月三者HPV16/18阳性率分别为1.9%、15.2%、27.35,术后12个月检测HPV16/l8阳性率分别为0.0%、1.5%,18.2%。三组CIN患者术前与术后6、12个月的HPV16/18阳性率相比差异有统计学意义(P<0.05)。结论:LEEP手术可以显著减少HPV16/18的阳性率,有效预防宫颈上皮内瘤变。

Objective： To explore the change and significance of human papillomavirus （HPV） 16/18 in cervical intraepithelial neoplasia （CIN） before and after loop electrosurgical excision procedure （LEEP） . Methods： The levels of HPV 16/18 itl 200 patients who were diagnosed as CIN by cervical biopsy, pathological examination, and colposcopy and treated with LEEP were detected before LEEP and at 6 and 12 months after LEEP. Results： The positive rates of HPV 16/18 in cervical tissues of patients with CINI, CIN ]I, and CINIII were 42. 0%, 63.6%, and 81.8% before LEEP, 1.9%, 15.2%, and 27. 3% at 6 months after LEEP, 0.0%, 1.5%, and 18. 2% at 12 months after LEEP. There was statistically significant difference in the positive rate of HPV 16/18 in the three groups between before before LEEP and at 6 and 12 months after LEEP （P 〈 0. 05） . Conclusion： LEEP can significantly reduce the positive rate of HPV 16/18 and prevent CIN effectively.