HE4对不同年龄段卵巢癌的诊断价值评估

Evaluation of diagnostic value of HE4 for patients with ovarian cancer in different age groups

目的:探讨血清人附睾分泌蛋白4(HE4)对不同年龄段卵巢癌的诊断差异和临床意义。方法:收集女性卵巢癌术前血清标本160例、女性盆腔良性疾病患者血清标本45例及女性健康人血清标本109例测定HE4浓度,分析HE4在不同年龄阶段的差异和诊断能力。结果:卵巢癌组血清HE4浓度高于良性组和健康对照组(P<0.001)。三组各年龄阶段的HE4浓度比较差异有统计学意义(P<0.001和P=0.005)。青中老年组的最佳诊断点分别为75、80、130pM。结论:血清HE4能够很好地诊断卵巢癌,但在老年人群中诊断能力稍差。

Objective： To explore the diagnostic difference and clinical significance of serum human epididymal secretory protein 4 （HE4） for patients with ovarian cancer in different age groups. Methods： HE4 concentrations in serum samples of 160 women with ovarian cancer before operation, 45 women with pelvic benign diseases, and 109 health y women were detected, the differences and diagnostic capa- bilities of HFA in different age groups were analyzed. Results： The serum concentration of HFA in ovarian cancer group was statistically sig- nificantly higher than those in benign group and healthy control group （P 〈 0. 001 ） . In the three groups, there was statistically significant difference in the concentration of HE4 among the women in different age groups （P 〈 0. 001 and P = 0. 005 ） . points in young, middle - aged, and old groups were 75, 80, and 130 pM, respectively. Conclusion： HE4 can be used a good index to diagnose ovarian cancer , but its diagnostic capability is poor in elderly population.