原发性高血压儿童血尿酸与动态血压的相关关系

The correlation between the serum uric acid and ambulatory blood pressure in children with primary hypertension

目的探讨原发性高血压儿童血尿酸(SUA)与动态血压(ABP)的相关关系。方法以我院原发性高血压汉族儿童为研究对象,以健康儿童作对照。首先直线回归分析探讨SUA与ABP关系;然后以年龄和性别构成为协变量,进行Logistic回归分析;最后以年龄、性别构成及体重指数为协变量,进行多元回归分析,探讨血尿酸与ABP的关系。结果直线回归分析显示SUA与24-h SBP、白昼SBP、夜间SBP、24-h DBP和夜间DBP呈正相关(P<0.05);调整年龄和性别构成后Logistic回归分析和调整了年龄、性别构成及体重指数后多元回归分析均显示,SUA与24-hSBP、夜间SBP、24-h DBP和夜间DBP呈正相关(P<0.05)。结论随着SUA增加,儿童原发性高血压风险增加。

Objective To know the correlation between the serum uric acid （SUA） and ambulatory blood pressure （ABP） in children with primary hypertension. Methods A total of 110 patients were included in the study, and 110 healthy children were cllected as compared. Linear regression analysis, logistic regression analysis and multiple regression analysis were used to explore the relationship of SUA and ABP. Results SUA was significantly associated with 24-h SBP, diurnal SBP, nocturnal SBP, 24-h DBP and nocturnal DBP according to the linear regression analysis （P 〈 0.05）. SUA was significantly associated with 24-h SBP, nocturnal SBP, 24-h DBP and nocturnal DBP after adjusting for age and gender according to the logistic regression analysis; SUA was significantly associated with 24-h SBP, nocturnal SBP, 24-h DBP and nocturnal DBP after adjusting for age and gender according to the multiple regression analysis, too. Conclusion Among.children at risk for hypertension, the likelihood for diastolic hypertension increases significantly as SUA increases.