盐酸莫西沙星治疗肝硬化并发自发性腹膜炎的疗效研究

Efficacy of moxifloxacin hydrochloride for spontaneous bacterial peritonitis complicated with hepatocirrhosis

目的研究盐酸莫西沙星治疗肝硬化并发自发性腹膜炎的临床疗效和安全性。方法前瞻性选取肝硬化并发自发性腹膜炎患者43例,采用盐酸莫西沙星0.4g静脉滴注,1次/d,抗腹腔感染治疗,评价其临床疗效和安全性。结果 43例患者中治愈28例占58.14%、好转13例占30.23%,总有效率为88.37%;药物不良反应发生率为6.98%。结论盐酸莫西沙星治疗肝硬化并发自发性腹膜炎临床疗效好,安全性高,可作为经验性抗菌药物治疗。

OBJECTIVE To explore the clinical efficacy and safety of moxifloxacin hydrochloride in treatment of spontaneous bacterial peritonitis（SBP） complicated with hepatocirrhosis.METHODS A total of 43 patients who were diagnosed SBP with hepatocirrhosis were enrolled in the prospective study.All of them were treated with moxifloxacin hydrochloride by intravenous infusion with a dose of 0.4 g,once a day for anti-abdominal infections treatment.The clinical efficacy and the safety were evaluated.RESULTS Of 43 cases of patients,28 cases were cured,accounting for 58.14%,13 cases were improved,accounting for 30.23%,the total effective rate was 88.37%,and the incidence rate of adverse drug reaction was 6.98%.CONCLUSION Moxifloxacin hydrochloride has good clinical efficacy and safety in the treatment of SBP complicated with hepatocirrhosis,which can serve as empirical antibiotics treatment.