米尔贝肟对自然感染疥螨病犬的治疗效果

Efficacy of milbemycin oxime for the treatment of sarcoptic mange in dogs

为了评价米尔贝肟对临床自然感染疥螨犬的治疗效果,选用自然感染疥螨犬65例,随机选择5条服用伊维菌素,另外60条随机分为3组,分别服用高剂量(2g/kg体重)、中剂量(1g/kg体重)、低剂量(0.5g/kg体重)的米尔贝肟。给药后2、14、28、42d和56d,刮取皮屑,检查螨虫和虫卵,同时观察临床症状。试验结束时米尔贝肟高剂量组、伊维菌素组的无螨虫犬的比例和螨虫的下降率均为100%,临床症状如红疹、结痂、过度角化等现象均消失,所有动物毛发都开始大范围重生;米尔贝肟中、低剂量组结果稍差。米尔贝肟按2g/kg体重剂量,每周1次,连续用药3周,给药对自然感染疥螨病犬有很好的治疗效果。

Milbemycin oxime tablets were evaluated for efficacy against sarcoptic mange mites in natu- rally infected dogs. Sixty-five dogs were randomly allocated to four groups and were housed individually. Five of the dogs were treated orally with ivermectin at the proposed dose. The other sixty dogs were trea- ted with milbemycin oxime at the proposed minimum, middle and maximum doses （0.5 g/kg, 1.0 g/kg and 2.0 g/kg）. To enumerate Sarcoptes scabiei mites, skin scrapings were taken on Day 2, 14, 28, 42 and 56. Clinical signs of mange and the extent of Sarcoptic lesions were evaluated on each dog when scrapings were made. Evaluation of the efficacy of the treatment was based on the absence of mites supported by the absence of clinical signs associated with canine sarcoptic mange. Treatment with maximum dose rate of milbemyein oxime at weekly intervals and ivermectin resulted in a rapid reduction of mites and improved clinical signs. The overall cure rates at Day 56, based on zero mite counts and resolution of clinical signs were 100 %, while treatment with middle and minimum dose rate of milbemycin oxime at weekly intervals resulted in relative poor results. Weekly treatment with maximum dose（ 2.0 g/kg） rate of milbemycin ox- ime for continually three weeks, was effective for the treatment of sarcoptic mange in dogs.