PEG大分子硅氧烷制备药物缓释杂化纳米纤维膜

Preparation of Hybrid Nanofiber Membrane via Siloxane Functionized PEG as Drug Release System

采用Jones试剂对聚乙二醇(PEG)进行修饰并合成端基为-Si(OEt)3的PEG大分子硅氧烷,将其与TiO2溶胶进行共水解缩合,制得PEG/SiO2-TiO2杂化纺丝液。在杂化纺丝液中加入头孢唑啉钠,经静电纺丝法制备载药杂化纳米纤维膜。对杂化电纺纤维膜的结构与形态进行了表征,并研究了其药物释放性能。红外光谱(FT-IR)研究了PEG大分子硅氧烷合成机理和产物结构;扫描电镜(SEM)照片显示,纳米纤维的平均直径约为115 nm,载药纳米纤维平均直径约为130 nm;紫外可见光(UV-Vis)光谱分析表明,载药纤维的初期释放速度较快,随时间推移释放速率逐渐降低,具有良好的药物缓释性能。

Polyethylene glycol（PEG）was reacted with Jones reagent and siloxane functionized PEG was prepared,PEG/SiO2-TiO2 hybrid sol was prepared by the hydrolysis and co-condensation of siloxane functionized PEG with TiO2 sol.Using cefazolin sodium as encapsulated drug,hybrid drug-loaded nanofiber membrane was prepared via electrospinning method.The morphology,chemical structure and drug release capability of the hybrid membrane were studied.The reaction mechanism was investigated via FT-IR spectra.SEM images showed that diameter of the hybrid nanofiber was about 115 nm,while that of the drug loaded nanofiber was about 130 nm.UV-Vis analysis showed that the drug release rate of drug-loaded fiber was high at an initial stage,and the rate decreased gradually with time prolonging,the hybrid membrane showed well performance of drug release.