基于巯基点击反应与RAFT聚合的功能性聚合物合成

Synthesis of Functional Polymers via Combination of Thiol-Based Click Reactions with RAFT Polymerization

可逆加成-裂解链转移聚合(RAFT)由于单体适用面广、聚合条件温和、不受聚合方法的限制等特性,已经成为活性合成聚合物的有效手段之一。点击化学(click chemistry)由于具有良好的选择性、模块性以及官能团耐受性等特点迅速成为许多研究领域,如药物、聚合物、功能材料等合成的有力工具,同时涌现出了多种基于巯基的点击反应。本文综述了近年来基于巯基的点击反应,如巯基-烯、巯基-炔、巯基-异氰酸酯、巯基-环氧化物以及巯基-卤代烃等新型点击反应与RAFT聚合相结合在功能性聚合物的制备和修饰中的应用,相信这两种手段的结合将在其中发挥积极的作用。

Due to wide range of monomers, mild polymerization conditions and various established polymerization methods, reversible-addition-fragmentation chain transfer （RAFT） polymerization is a useful living polymerization technique for the design and synthesis of polymers. Click chemistry has been demonstrated as a powerful tool in numerous scientific fields including drugs, polymers and functional materials because of its superior selectivity, modularity and functional group tolerance. At the same time, a series of novel thiol-based click reactions thus emerged. Herein, recent tactics that combine thiol-based click reactions, such as thiol-ene, thiol- yne, thiol-icocyanate, thiol-oxirane and thiol-halo with RAFT technique toward the construction and modification of useful functional polymers are reviewed. The combined thiol-based click reaction/RAFT technique is believed to play a positive role in the design and synthesis of functional polymers.