失用性失写的脑机制

Neural Mechanism of Apraxia Agraphia

失用性失写是指人们知道该如何书写,但实际上却不会书写或错误书写的一种现象。失用性失写涉及的神经网络包括皮层与皮层连接、皮层与皮质下连接。其中前者包括额-顶叶相关脑区的连接、顶-枕叶相关脑区的连接以及额-顶-枕相关脑区的连接,这些神经网络分别负责操作空间表征图像、回忆以及检索字母的形状等;后者包括小脑与额-顶叶的连接、左丘脑-大脑皮质的连接以及纹状体-内囊-左额顶叶的连接等,它们分别与图像输出程序、书写运动过程、操作指令的执行过程以及字素形成过程等有关。今后的研究应该集中在完善失用性失写的研究范式、深入探讨失用性失写的心理机制以及推动其康复工作的开展等方面。

Apraxic agraphia refers to the phenomenon that people can＇t write or can＇t write correctly though they know how to write. The neural network involving in apraxic agraphia includes the cortico-cortical connection and cortico-subcortical junction. Three subtypes involved in the cortico-cortical connection include the frontal-parietal junction, the parieto-occipital connection and the network which is associated with the frontal lobe, parietal lobe, occipital lobe and temporal lobe. These subtypes are in charge of the spatial manipulations of represented images, recalling and retrievaling the forms of characters. The other neural network is the cortico-subcortical junction, which consisted of the cerebell^r-cortical connection, thalamo-cortical junction, and the network including the corpus striatum, internal capsule and cerebral cortex. They are related to the graphic output programming, the formation of grapheme, and the praxis command. Future researches need focus on psychological and mental mechanism.of apraxic agraphia and rehabilitation work of it.