摘要
树突状细胞相关凝集素受体1和2(Dectinl和2)是2C型凝集素受体家族(CLR)的重要成员,作为模式识别受体(PRRs),其有效地识别病原体相关分子模式(PAMPs);Dectin-1识别β-葡聚糖,通过自身免疫受体络氨酸激活基序(ITAM)向胞内转导信号;Dectin-2识别α-甘露聚糖,通过耦联FcRγ链上的ITAM结构转导信号。ITAM招募并激活非受体络氨酸蛋白激酶(Syk),后者激活MAPKs或介导CARD9-Malt1-Bcl10复合体组装,激活核因子-κB(NF-κB),诱导合成炎症因子等一系列细胞活动。其配体β-葡聚糖和甘露聚糖都是真菌细胞壁的主要成分。近年来研究表明,Dectin-1和Dectin-2受体在真菌免疫防御中具有重要作用。
DC-associated C-type lectin-1 and 2 (Dectin-1 and Dectin-2) are pivotal C-type lectin family members, both of them function as pattern recognition receptors (PRRs) to initiate innate and adaptive immunity by recognizing pathogen-associated molecular patterns (PAMPs). Dectin- recognizes β-glucans and signals with its cyoplasmic immunoreceptor tyrosine-based activation motif (ITAM)-like motif, whereas Dectin- 2 recognizes α-mannans and signals through association with the ITAM-containing Fc receptor γ chain. Upon ligand ligation, spleen tyrosine kinase (Syk) is recruited to the ITAM. Syk mediates the activation of MAPKs; or induces the formation of the CARD9-Maltl-Bc110 complex, resulting in the activation of nuclear factor-KB (NF-κB). Recert studies indicate that Dectin-1 and Dectin-2 play important roles in immune defense against fungi.
出处
《国际免疫学杂志》
CAS
2012年第5期358-361,共4页
International Journal of Immunology
基金
基金项目:中央高校基本科研业务费专项资金(10ykpy04)