摘要
目的:通过对溃疡性结肠炎(Ulcerative Colitis,UC)组织中白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)和转化生长因子-β1(TGF-β1)表达水平的检测,探讨它们在UC发生、发展过程中的作用。方法:①实验分组:UC组(90例);正常对照组(30例)。②IL-8、TNF-α和TGF-β1表达水平的检测:应用放射免疫法(RIA)检测三者在UC组、正常对照组血清中的表达水平。结果:UC组血清中IL-8、TNF-α表达水平与正常对照组相比明显增高(P<0.01),并与临床上病情的严重程度相一致;血清中TGF-β1的含量UC组高于正常对照组(P<0.05)。结论:UC组IL-8、TNF-α和TGF-β1的含量明显升高,提示IL-8、TNF-α和TGF-β1在UC的发病机制中起重要作用。
Objective： To detect the expressions of interleukin- 8（ IL- 8）, tumor necrosis factor α（TNF- α） and transforming growth factor -β （TGF- β ）in human ulcerative colitis（UC） tissues, and to investigate the role of those in the progression of ulcerative colitis. Methords： （1）Experiment group： UC group（90 cases） ;nomal control（30 cases）. （2）The expressions of IL - 8, TNF - α and TGF - β1 in the serum of UC group and nomal control were detected by radioimmunoassay（RIA）. Result： OThe serum levels of IL- 8 and TNF-α were sig- nificantly higher in UC group than those in nomal control（P 〈 0.01 ）, and these changes were corresponding to the clinical symptoms. And there was obviously difference in the serum level of TGF - β1 between UC group and nomal control（ P 〈 0.05）. Conclusion： IL - 8, TNF -α and TGF- β1 maybe play an important role in the patho- genesis of UC.
出处
《内蒙古医学杂志》
2012年第6期641-644,共4页
Inner Mongolia Medical Journal
