甲硝唑联合乳杆菌活菌胶囊治疗细菌性阴道病疗效观察

Observation of therapeutic effect of combination of metronidazole and lactabacillus on bacterial vaginosis

目的观察甲硝唑联合乳杆菌活菌胶囊治疗细菌性阴道病(bacterial vaginosis,BV)的临床效果及复发情况。方法将1200例门诊BV患者分为四组,每组各300例。A组予甲硝唑口服,0.2 g bid,共7天;B组睡前予乳杆菌活菌胶囊阴道给药,共10天;C组口服甲硝唑7天,同时在阴道深部放置乳杆菌活菌胶囊10天;D组阴道放置甲硝唑阴道泡腾片7天后,再阴道放置乳杆菌活菌胶囊10天,共治疗17天。结果 A、B、C、D组的总有效率分别为90.00%、81.36%、91.08%和93.16%,A、C、D组间差异无统计学意义(P>0.05),但均明显优于B组,差异有统计学意义(P<0.05);A与B、C与D组间复发率比较,差异无统计学意义(P>0.05);A、B组的复发率明显高于C组和D组,差异有统计学意义(P<0.05)。结论甲硝唑联合阴道放置乳杆菌活菌胶囊治疗BV疗效好,复发率低。

Objective To observe the efficacy and recurrence rate of combination of metronidazole and lactabacillus in the treatment of patient with bacterial vaginosis （BV）. Methods One thousands and two hundred outpatients with bacterial vaginosis were randomly divided into 4 groups. In group A, patients received oral metronidazole tablets （0.2 g） , twice per day for 7 days. In group B, patients received lactabacillus for 10 days. In group C patients received oral metronidazole tablets for 7 days, and at the same time the lactabaeillus was placed in deep site of vagina for 10 days. In group D ,patients had vaginal administration of metronidazole for 7days be- fore the lactabacillus was placed in deep site of vagina for 10 days. Results The clinical efficacy were 90.00% in group A ,81.36% in group B ,90.71% in group C and 93.16% in group D, respectively. The efficaeies of groups A, C and D were better than that of group B（ all P 〈 0. 05 ）although there was no statistically significance among the three groups. Moreover,the recurrence rate of group A and B was higher than that of group C and D （ P 〈 0.05 ）. Condusions Combination of metronidazole and lactobaeillus may be more effective with lower recurrence rate in treating BV than metronidazole or laetobacillus alone.