摘要
目的卡培他滨的新合成工艺研究。方法以5-氟尿嘧啶、六甲基二硅胺烷为起始原料合成卡培他滨。结果该方法收率70.1%,目标产物纯度99.0%,其结构采用1H-NMR和熔点仪进行测定并进行元素分析表征。结论该工艺路线简单,收率与现有工艺相当,适合工业化生产。
Objective To study a new synthesis process of capecitabine. Methods Capecitabine was prepared with 5 - fluorouracil and hexamethyl silicon amine alkyl as starting materials. Results The total yield was 70.1% and the purity of prod- uct was 99.0%. The structure of product was confirmed by 1H - NMR and melting point apparatus, also elemental analysis was carried out. Conclusion The process was simple with yield corresponding to the existing process, and it was suitable for indus- trial production.
出处
《齐鲁药事》
2012年第8期442-443,447,共3页
qilu pharmaceutical affairs
关键词
卡培他滨
合成
抗肿瘤
Capecitabine
Synthesis
Anti - tumor
