0.5%噻吗洛尔溶液局部治疗婴幼儿血管瘤的疗效观察

Effectiveness of 0.5% Solution of Topical Timolol Maleate for Infantile Hemangiomas

目的评价0.5%噻吗洛尔溶液局部治疗婴幼儿血管瘤的临床疗效和安全性。方法25例婴幼儿血管瘤患儿给予0.5%马来酸噻吗洛尔溶液血管瘤表面外用(30μL/cm2);对照组共17例婴幼儿血管瘤患儿给予生理盐水血管瘤表面外用(30μL/cm2)。每8 h使用1次,1天3次。每个月定期门诊复查,持续6个月,定期观察和记录血管瘤大小、质地、颜色变化,若出现严重症状和体征者及时给予对症治疗。结果治疗组疗效评定:优1例,好4例,中11例,差9例,总有效率64.00%;对照组疗效判定:优0例,好0例,中3例,差14例,总有效率17.65%。两组差异显著(P<0.05)。治疗组无明显不良反应。结论0.5%噻吗洛尔溶液局部治疗浅表型婴幼儿血管瘤疗效明显,不良反应少,患儿耐受性好。

Objective To investigate the clinical efficacy and safety of 0.5% solution of topical timolol maleate for infantile hemangiomas. Methods A total of 25 infants with hemangiomas were treated by 0.5% solution of timolol maleate topically every eight hours in a thin layer （30 μL/cm2） as treatment group, while 17 cases of infants with hemangiomas were treated with normal saline topically every eight hours in a thin layer （30 μL/em2） as control group. The parents are responsible for topical application of drug every day. The treatment lasted for six months and the patients were visited once a month. The changes of tumor size, texture and color were monitored and recorded at a regular interval. Symptomatic treatment was given timely for any acute signs and symptoms. Results In treatment group, the overall response of excellent was evaluated in 1 patient, good in 4 patients, moderate in 11 patients, poor in 9 patients, and the total effective rate was 64.00%. In control group, the overall response of excellent was evaluated in 0 patient, good in 0 patient, moderate in 3 patients, poor in 14 patients, and the effective rate was 17.65%. There was significant difference between the two groups （P〈0.05）. No obvious adverse reactions were observed. Conclusion Topical timolol maleate shows good therapeutic effect for superficial hemangiomas with good drug tolerability and minor adverse reaction.