儿童喉乳头状瘤方的急性毒理实验

The acute toxicity test of the Juvenile Laryngeal Papilloma(JLP) Prescription

目的观察儿童喉乳头状瘤方的急性毒性反应。方法对对照组和中药组小鼠采用最大给药量毒性实验法,记录14 d内小鼠的外观、饮食、活动、排泄、体重及死亡等情况,于解剖后观察其重要脏器(心、肝、脾、肺、肾、胃、肠等)的变化。结果急性毒性实验小鼠灌胃给药最大耐受量相当于患儿临床日用量的206倍,中药组与对照组一般表现、主要脏器均未见明显异常改变,14 d内两组体重差异无统计学意义(P>0.05)。结论儿童喉乳头状瘤方拟定剂量及途径在临床应用上是安全的。

Objective To observe the acute toxicity of the JLP Prescription. Methods The maximum administered dose toxicity test method between the control group and the Chinese medicine group in mice were used. The appearance, diet, activity, ex cretion, body weight and death in mice within 14 days were observed. The changes in vital organs （heart, liver, spleen, lung, kidney, stomach, intestines, etc.） were observed after anatomy. Results Acute toxicity test in mice confirmed that the maximum tolerated dose was equivalent to 206 times of daily dose for the children in clinical, the general performance and major organs in the traditional Chinese medicine group and control group all showed no obvious abnormalities, it found that no signifi- cant difference in body weight in 14 days. Conclusion JLP Prescription dose and route of administration is safe in clinical.