水蛭逐瘀胶囊联合葛根素治疗短暂性脑缺血发作疗效观察

Effect observation of leech stasis capsule combined with puerarin injection in treatment of transient ischemic attack(TIA)

目的观察口服水蛭逐瘀胶囊联合注射用葛根素静滴治疗短暂性脑缺血发作的疗效及其对血液流变学的影响。方法将2003年10月～2010年10月在本院住院治疗的短暂性脑缺血发作患者100例随机分为两组,治疗组50例,在口服水蛭逐瘀胶囊基础上联合静滴注射用葛根素;对照组50例,静滴注射用盐酸丁咯地尔,两组疗程均为15d,比较两组疗效。结果治疗组总有效率为96.00%,对照组为82.00%,两组比较差异有统计学意义(P﹤0.05)。治疗后治疗组的全血高切黏度、全血低切黏度、血浆黏度均明显下降,与对照组比较,差异有统计学意义(P<0.01)。而两组治疗前后血细胞比容均无明显变化,两组均无不良反应。结论口服水蛭逐瘀胶囊联合注射用葛根素静滴治疗短暂性脑缺血发作有显著疗效。

Objective To observe the clinical effect of leech stasis capsule combined with puerarin injection in treatment of transient ischemic attack （TIA）. Methods One hundred patients with TIA in our hospital from October 2003 to October 2010 were randomly divided into two groups. Fifty cases of treatment group were given puerarin injection by intravenous infusion on the basis of leech stasis capsule orally; 50 cases of control group were given buflomedil hydrochloride injection by intravenous infusion. Fifteen days were a course. The curative effects of the two groups were compared. Results The to- tal effective rate was 96.00% in treatment group and 82.00% in control group. The difference was significant （P 〈 0.05）. High shear blood viscosity, low shear viscosity of whole blood and plasma viscosity decreased in treatment group after treatment, and the difference was significant （P 〈 0.01） compared with the control group. Whereas the hematocrit of the two groups was no statistically change before and after treatment. Both of the two groups have no adverse reaction after treat- ment. Conclusion Leech stasis capsule combined with puerarin injection in treatment of TIA has a significant effect.