幽门螺旋杆菌感染与桥本甲状腺炎的关系

Relationship between infection of Helicopacter Pylori and Hashimoto's thyroiditis

目的探讨幽门螺旋杆菌(Hp)感染与桥本甲状腺炎的关系。方法比较246例桥本甲状腺炎患者及120例健康对照者Hp感染率,再将166例幽门螺旋杆菌IgG抗体阳性的桥本甲状腺炎患者随机分为83例抗Hp治疗组和83例未予抗Hp治疗的观察组,6个月后分别比较两组治疗前后甲状腺过氧化酶抗体(TPOAb)与甲状腺球蛋白抗体(TGAb)滴度的变化。结果桥本甲状腺炎组Hp感染率为67.5%,高于健康对照组53.3%,两组比较有统计学差异(P<0.01);Hp抗体阳性的桥本甲状腺患者中,抗Hp治疗组治疗后TPOAb及TGAb的滴度较治疗前均明显下降(P<0.01),观察组无明显变化。结论 Hp感染可促进桥本甲状腺炎的发生及发展,抗Hp治疗将可能有助于桥本甲状腺炎的治疗。

Objective To study the relationship between Helicobacter pylori （Hp） infection and Hashimoto thyroiditis. Methods The prevalence of Hp infection in 246 patients with Hashimoto＇s thyroiditis and 120 healthy controls was com pared,and then 166 Hashimoto＇s thyroiditis patients with positive Hp IgG antibody were randomly divided into 83 Hp eradication treatment group and 83 non Hp intervention observational group. Serum titers of thyroid peroxidase antibodies （TPOAh） and thyroglobulin antibody （TGAb） in these 166 patients were tested before and after the 6 months＇ treatment. Results The prevalence of Hp infection in patients with Hashimoto＇s thyroiditis is significantly higher than in healthy volun teers （67.8% vs 53.3% ,P 〈 0.01）. In the Hashimoto＇s thyroiditis patients with positive Hp IgG antibody,the serum titers of TPOAb and TGAb reduced significantly after 6 month with those in Hp eradication treatment group than those in observational group. Conclusion The association between Hp infection and Hashimoto＇s thyroiditis suggests a possible role of this bacterium in the onset and the progress of the disease. Hp eradication treatment may be a potential therapy to Hashimoto＇ s thyroiditis.