缬沙坦联合前列腺素E1治疗早期糖尿病肾病的疗效研究

Clinical effect of Valsartan combined with Eprostaglandin E1 in the treatment of patients with early diabetic nephropathy

目的探讨缬沙坦联合前列腺素E1治疗早期糖尿病肾病(DN)的临床效果。方法将68例早期DN患者随机分为研究组和对照组各34例,对照组给予缬沙坦常规治疗,研究组在对照组基础上加用前列腺素E1治疗。结果研究组治疗后24 h白蛋白尿排泄率、血肌酐水平均明显低于对照组(P<0.05)。研究组的临床疗效显著高于对照组(P<0.05)。结论缬沙坦联合前列腺素E1可以有效地改善早期DN症状,更好地保护肾功能。

Objective To explore the clinical effect of Valsartan combined with Eprostaglandin E1 on early diabetic nephropathy. Methods Sixty-eight cases of early diabetic nephropathy patients were randomized into study group and con trol group with 34 case each group. The control group was given conventional treatment and Valsartan. The study group was given Valsartan combined with Eprostaglandin E1 on the base of control group. Results The 24 hour urinary albumin excretion rate （UAER） and serum creatinine （Scr） in study group were significantly lower than in control group（P 〈 0.05）. The clinical efficacy in study group was higher than in control group （P 〈 0.05）. Conclusion Valsartan combined with E prostaglandin E1 on early diabetic nephropathy has a better effect in improving function of early diabetic nephropathy.