血清胱抑素C与缺血性心衰患者及其近期预后关系的探讨

The investigation of relationship between serum cystatin C and the patients with ischemic heart failure and short term prognosis

目的探讨血清胱抑素C(CysC)水平与缺血性心力衰竭(心衰)患者及近期预后的关系。方法收集并测定95例缺血性心衰患者及80例冠心病无心衰患者血清胱抑素、肌酐等指标,比较两组患者血清CysC水平;将心衰患者分为高CysC组及低CysC组,比较两组患者3个月心血管事件、病死率和再入院率情况差异;分析心衰组患者胱抑素与BNP、肌酐、C反应蛋白等的相关性。结果缺血性心衰患者较无心衰患者胱抑素C水平升高明显,差异具有统计学意义(P<0.05);高血清CysC组患者3个月心血管事件、病死率和再入院率明显增加,与低血清CysC组比较差异有统计学意义(P<0.05);相关分析显示血清CysC与肌酐、脑钠肽(BNP)呈显著正相关(P<0.05)。结论缺血性心衰患者血清CysC水平明显高于非心衰患者,血清CysC水平有可能成为诊断缺血性心衰的一标志物;CysC水平与缺血性心衰患者近期预后有密切的关系,血清CysC可能成为为缺血性心衰患者近期预后的预测因子。

Objective To investigate the relationship between Serum Cystatin C （CysC） and the patients with ischemic heart railure and short term prognosis. Methods The CysC and creatinine were collected and compared from the 95 patients with ischemic heart failure and 80 patients with non-ischemic heart failure; the patients with ischemic heart failure were devid ed into high CysC group and low CysC group, and the difference of cardiovascular events in three months, mortality and readmission rate of two groups were compared; the correlation of CysC, BNP, Creatinine and CRP were analysised in is chemic heart failure group. Results Compared with non-ischemic heart failure group, CysC of ischemic heart failure group was higher （P 〈 0.05）; compared with low CysC group, the cardiovascular events in three month, mortality and readmission rate in high CysC group was higher （P 〈 0.05）; the correlation analysis shows the CysC was significantly positive with BNP and creatinine （P 〈 0.05）. Conclusion The CysC level of ischemic heart failure group was obviously higher than that of the non-is chemic heart failure group, and the CysC level may be one marker to diagnosis the ischemic hart failure; the CysC level was closely related with the prognosis of ischemic heart failure patients, and the CysC may be a predictor of the short term prognosis of ischemic heart failure patients.