依达拉奉联合高压氧治疗一氧化碳迟发性脑病疗效观察

Observation of the curative effect of edaravone combined with hyperbaric oxygen therapy in treating delayed encephalopathy after acute carbon monoxide poisoning

目的探讨急性一氧化碳迟发性脑病(DEACMP)的有效治疗方法及效果。方法选择急性一氧化碳中毒住院患者62例,治疗组31例,采用依达拉奉+高压氧治疗+内科治疗的方法。对照组31例,采用高压氧治疗+内科治疗;监测两组治疗前后血清丙二醛(MDA)浓度观察其临床疗效。结果治疗组治疗后血清MDA浓度较治疗前明显降低(P<0.05),对照组变化不明显(P>0.05);治疗组有效率90.32%,对照组有效率为64.51%,两组治疗效果比较差异有显著性(P<0.05),治疗组效果优于对照组。结论依达拉奉可能在一氧化碳中毒迟发脑病患者的治疗过程中发挥重要作用。

Objective To explore the curative effect of treatments for patients with delayed encephalopathy after acute carbon monoxide poisoning（DEACMP）. Methods 62 cases of DEACMP were divided into treatment group （31 cases） and control group （31 cases）. The control group was received hyperbaric oxygen therapy and medical treatment, the treatment group were treated with edaravone additionally on the basis of the basic treatment. Serum levels of malondialdehyde（MDA） and clinical effect were observed before treatment and after treatment in both groups. Results Serum levels of MDA after treatment were significantly lower than those before treatment in the treatment group （P 〈 0.05）,however there were no significant difference between serum levels of MDA before treatment and after treatment （P 〉 0.05） in the control group; the total effective rate of treatment group was 90.32% ,and the total effective rate of control group was 64.51%. There was a significant difference in two groups （P 〈 0.05）.The curative effect in treatment group was significantly superior to those in the control group. Conclusion Edaravone play an important role in the treatment of patients with DEACMP.