痛泻宁颗粒治疗肝郁脾虚型溃疡性结肠炎30例

Effective Study of Tongxiening Granules in Treating Ulcerative Colitis with Stagnation of Live-Qi and Deficiency of Spleen

目的观察痛泻宁颗粒治疗肝郁脾虚型溃疡性结肠炎(UC)的临床疗效与安全性。方法将61例溃疡性结肠炎患者随机分成治疗组和对照组。治疗组30例,采用口服痛泻宁颗粒治疗,每日3次,每次5 g;对照组31例,采用口服柳氮磺胺吡啶(SASP)治疗,每次1.0 g,每日4次。两组疗程均为8周。结果治疗组总有效率为90.00%,明显高于对照组的80.65%;中医证候缓解率,治疗组为90.00%,明显高于对照组的74.19%(P<0.05);两组总有效率、中医证候缓解率比较,差异均有统计学意义(P<0.05);服药后的不良反应,治疗组明显少于对照组(P<0.05)。结论痛泻宁颗粒治疗肝郁脾虚型溃疡性结肠炎疗效明显优于柳氮磺胺吡啶,且不良反应少。

Objective To observe the clinical efficacy and safety of Tongxiening Granules in treating ulcerative colitis（UC）with the stagnation of live-Qi and the deficiency of spleen.Methods 61 cases of UC were randomly divided into the treatment group and the control group.The treatment group（30 cases）adopted oral Tongxiening Granules,3 times daily,5 g each time.The control group（31 cases）was treated by oral sulfasalazine（SASP）,1.0 each time,4 times a day.After the end of 8-week treatment course,the clinical curative effects and the difference between syndrome relieving of traditional Chinese medicine were observed.Results The clinical efficacy in the treatment group was 90.00%and significantly higher than 80.65%in the control group.The Chinese medicine syndrome remission rate in the treatment group was 90.00%and significantly higher than 74.19%in the control group（P 〈 0.05）,all showing statistical differences between the two groups（P 〈 0.05）.The adverse reactions after taking medication in the treatment group were obviously less than those in the control group（P 〈 0.05）.Conclusion The curative effect of Tongxiening Granules for treating UC with the stagnation of live-Qi and the deficiency of spleen is obviously superior to SASP with less adverse reactions.