氨氯地平联合厄贝沙坦在高血压肾病中的应用研究

Effect of amlodipine combined with irbesartan on hypertensive nephropathy

目的探讨氨氯地平联合厄贝沙坦在高血压肾病中的应用效果。方法 2011年1月—2012年1月收治高血压肾病患者160例,随机分为观察组和对照组,每组80例。对照组采用厄贝沙坦150 mg口服,每日1次;观察组另加用氨氯地平5 mg口服,每日1次。均治疗2个月。结果观察组总有效率明显高于对照组(91.25%vs72.50%,P<0.05);2组SBP、DBP、24 h尿蛋白均明显低于治疗前,且观察组明显优于对照组(P<0.05);2组不良反应发生率差异均无统计学意义(13.75%vs 17.50%,P>0.05)。结论氨氯地平联合厄贝沙坦治疗高血压肾病效果确切,可协同改善患者的高血压及肾功能,且安全可靠。

Objective To investigate the effect of anilodipine and irbesartan on hypertensive nephropathy.Methods 160 patients with hypertensive nephropathy were collected from Jan 2011 to Jan 2012.They were divided into 2 groups randomly. The control group used irbesartan（150 mg,per day） while the experimental group used anilodipine extra（5 mg,per day）.All patients were treated 2 months.Results The total effective rate of experimental group was better than control group （91.25%vs.72.50%,P 0.05）.Conclusion Use amlodipine and irbesartan treating hypertensive nephropathy is effective and safe,which can improve the hypertension and renal function.