α-硫辛酸治疗伴腹型肥胖的2型糖尿病勃起功能障碍临床研究

Clinical study of alpha lipoic acid in type 2 diabetic patients with abdominal obesity and erectile dysfunction

目的观察α-硫辛酸对伴腹型肥胖的2型糖尿病勃起功能障碍患者的疗效。方法选择伴腹型肥胖(腹型肥胖组)和不伴腹型肥胖(非腹型肥胖组)的2型糖尿病勃起功能障碍患者各30例。2组患者均予基础糖尿病治疗并加用α-硫辛酸,治疗3周后进行效果比较。结果治疗前,腹型肥胖组AUC、ISI、SOD、GSH-Px、NO、IIEF-5评分及内皮依赖性血管舒张功能均低于非腹型肥胖组(P<0.05),MDA、ET-1均高于非肥胖组(P<0.05),内皮非依赖性血管舒张功能2组无明显差异(P>0.05);治疗后,2组AUC、ISI、SOD、GSH-Px、NO、IIEF-5评分及内皮依赖性血管舒张功能均升高(p<0.05),MDA、ET-I均下降(P<0.05),且腹型肥胖组的改善幅度大于非腹型肥胖组(P<0.05),2组内皮非依赖性血管舒张功能均无明显变化(P>0.05)。结论α-硫辛酸能改善腹型肥胖2型糖尿病患者勃起功能障碍的胰岛β细胞功能、氧化应激状态和内皮功能,治疗糖尿病勃起功能障碍有良好效果。

Objective To observe the therapeutic effects of alpha lipoic acid（LA） in type 2 diabetes mellitus（DM） with abdominal obesity（AO） and erectile dysfunction（ED）.Methods All patients involved type 2 DM were divided into two groups：the AO group（30 type 2 DM patients with ED and AO） and the non AO group（30 type 2 DM patients with ED but without AO）.The therapeutic methods were similar of fundamental treatment plus alpha lipoic acid in both groups,and the period of therapy was 3 weeks.The comparison of results was performed before and after treatment.Results Before the LA treatment,the indexes of AUC,ISI,SOD,GSH-Px,NO,score of IIEF-5 and endothelium dependent dilation were lower in AO group than those in the non AO group（P 0.05）.After the LA treatment,the indexes of the AUC,ISI,SOD,GSH-Px,NO,score of IIEF-5 and endothelium dependent dilation increased significantly（P 0.05）.Conclusion It demonstrated that the LA could improve the beta cell function and the status of oxidative stress and endothelium function in type 2 DM patients with AO and ED, and was of good therapeutic effect for ED.