血管内皮生长因子与胎盘生长因子在妊娠期高血压患者血清中的表达

Study on the role of vascular endothelial growth factor and placenta growth factor in the pathogenesis of pregnant induced hypertension syndrome

目的探讨血管内皮生长因子(VEGF)与胎盘生长因子(PLGF)在妊娠期高血压(HDCP)发病中的作用。方法采用酶联免疫吸附法检测38例正常妊娠及41例HDCP患者血清VEGF与PLGF水平。结果与正常妊娠比较,HDCP患者分娩前血清VEGF与PLGF水平明显减少,差异有统计学意义(P<0.05);分娩后血清VEGF与PLGF水平无显著性差异(P>0.05)。结论 HDCP患者血清VEGF与PLGF水平减少,患者血清VEGF与PLGF水平与发病存在一定的相关性。

Objective To investigate the role of vascular endothelial growth factor （VEGF）and placenta growth tactor （PLGF）in the pathogenesis of hypertensive disorder complicating pregnancy （HDCP）. Methods forty-one patients with HDCP and thirty-eight noruml late pregnant women were observed in this study. For the assay of sermn concentrations of VEGF and PIGF, enzyme-linked imnmnosorbent assay was performed. Results The serum levels of VEGF and PIGF were significantly lower in HDCP group compared with the normal control group prior to birth （P〉0.05）;and were no different between HDCP group and the normal control group after parturition （/9〉0.05）. Conehlsions The serum levels of VEGF and P1GF were significantly lower in HDCP, which may be one of the major causes of the etiologies of HDCP.