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疏肝清热法调节非哺乳期乳腺炎Th1/Th2细胞平衡的研究 被引量:7

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摘要 目的检测非哺乳期乳腺炎患者外周Th,(IFN-γ)、Th。(IL-4)水平,观察疏肝清热法对非哺乳期乳腺炎患者Th1/Th2细胞因子的调节作用。方法以健康体检者33例为正常对照组,观察33例非哺乳期乳腺炎患者治疗前后外周血Th1(IFN-γ)、Th2(IL-4)、Th1/Th2(IFNγ/IL~4)表达情况。结果与正常对照组相比,非哺乳期乳腺炎患者外周血IFN-γ降低,IL-4升高,IFN-γ/IL-4降低,组间比较,有统计学意义(P〈0.050);与治疗前相比,经疏肝清热法治疗后IL-4明显降低,组间比较,有统计学意义(P〈0.050),IFN-γ、IFN-γ/IL-4有升高的趋势,但组间比较,无统计学意义(P〉0.050)。结论Th1/Th2细胞向Th2漂移可能参与非哺乳期乳腺炎的发病过程,并且同疾病的进展密切相关.疏肝清热法对非哺乳期乳腺炎的Th1/Th2细胞失衡有重要的调节作用。
出处 《医学信息》 2012年第7期103-104,共2页 Journal of Medical Information
基金 “十一五”国家支撑计划项目(2008BA1538083) 浦东新区科技发展基金创新资金项目(PR.12008-Y10)
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