缩宫素联合巧特欣用于产后出血的临床效果分析

Evaluate the Rapeutic Effect of Oxytocin Combined with Carbetocin Injection for Prevention of Postpartum Hemorrhage

目的评价临床上缩宫素联合巧特欣对于预防产后出血、降低孕产妇死亡率的疗效和安全性。方法将在我院自然分娩的240例产妇随机分为观察纽（120例）和对照纽（120例），对照纽常规给予缩宫素治疗，观察组在常规给予缩宫紊的基础上联合运用巧特欣，比较两组产时，产后2h，产后24h出血情况，子宫张力的改变情况。结果观察组与对照组相比，两组产妇的一般情况没有显著性差异，但是联合运用巧特欣时，产妇的产后出血量和出血发生率明显减轻，差异均有统计学意义（P〈0．05），并且胎盘娩出时长和对照组相比没有显著性差异（P〉0.05）。结论缩宫素联合巧特欣可以有效预防产后出血．安全性高．值得，临床推广应用。

Objective To evaluate the efficacy and safety of the clinical oxytocln combined with carbetocin injection for prevention of postpartum hemorrhage and reducing maternal mortality. Methods 240 cases of natural childbirth woman in our hospital were randomly divided into the observation group （120 cases） and control group （n = 120）, the control group used routine oxytocin treatment meanwhile the observation group used oxytocin combined with carbetocin injection. Observation the two groups of labor in hemorrhage and uterine tension change after postpartum 2h and 24h. Results In general, there was no significant difference between the observation group and the control group. Nevertheless, compared with control group, the combined of carbetocin injection in observation group could apparently reduce maternal postpartum hemorrhage and bleeding rate, the difference has statistics significance （P〈0.05）, and there is no difference in frequent rate between natural birth process and the control group （no significant difference P〉0.05）.Conclusion Oxytocin combined with carbetocin injection was effective in preventing postpartum hemorrhage and was safety in clinical treatment, which was worthy of clinical application.