牙周基础治疗对慢性牙周炎患者系统炎症水平的影响

The Effect of Non-surgical Periodontal therapy on Systemic Inflammation in Patients with chronic periodontits

目的探讨牙周基础治疗对慢性牙周炎患者系统炎症状况的影响。方法治疗组和对照组分剐纳入34和37例慢性牙周炎患者。观察牙周基础治疗后6周、3个月及6个月时的牙周状况和系统炎症因子水平。结果治疗组和对照组基线时的状况无显著差异（P〉0．05），提示两组间具有可比性。基础治疗后治疗组的菌斑指数、探诊出血百分比和牙周袋深度显著低于对照组（P〈0．05），治疗组的肿瘤坏死因子-α和白介素-6水平未有显著变化，且与对照组相比无显著差异（P〉0．05），治疗组的C反应蛋白从（2．73±2．78）mg／L降低到6个月时的2．23±2．05mg／L，且与对照组存在显著差异（P〈0．05）。结论牙周基础治疗能够有效的控制牙周感染，治疗效果在基础治疗后6个月达到最佳；牙周基础治疗能够有效的降低慢性牙用炎患者的系统C反应蛋白水平。从而起到改善机体炎症状况的作用；牙用感染可能是动脉粥样硬化和心血管疾病的一个危险因素．

Objective To evaluate the effect of non-surgical periodontal therapy on systemic inflammation in patients with chronic periodontits. Methods Thirty-four patients and thirty-seven patients with chronic periodontitis were randomly divided into the treatment and control groups. The periodontal and inflammatory status was observed during the 6 weeks, 3 months and 6 months after non-surgical periodontal therapy. Results At the baseline, there were no significant differences in the indices between the two groups （P 〉 0.05）. The plaque index, percentage of bleeding on probing and pocket probing depth were significantly lower in the treatment than in the control group （P 〈 0.05）. Tumor necrosis factor-α and interleukin-6 showed no significant difference between the groups （P 〉 0.05）. In the treatment group, the C reactive protein decreased from 2.73 ± 2.78mg/L at the baseline to 2.23 ± 2.05mg/L at the 6 month after therapy, and significantly lower than in the control group （P 〈 0.05）. Conclusion The periodontal infection can be controlled by non-surgical periodontal therapy, and the effect reached the best at the 6 months after therapy. The inflammatory status can be improved through C reactive protein by non-surgical periodontal therapy. The periodontal infection can be a risk factor for atherosclerosis and cardiovascular disease.