无抽搐电休克治疗与利培酮合并碳酸锂治疗躁狂发作的对照研究

Modified Electric Convulsive Therapy and Risperdal Merger Lithium Carbonate Treatment Manic Episodes of Control Study

目的比较无抽搐电休克治疗（MECT）与利培酮合并碳酸锂在治疗躁狂发作中的疗效及安全性。方法各型躁狂发作患者81例，随机分成两组，研究组患者在10次MECT治疗后用碳酸锂维持治疗，对照组以碳酸锂和利培酮联合治疗，连续观察6周，用躁狂量表（BRMS）治疗副反应症状量表（TESS）评定疗效及安全性。结果研究组治疗第1、2、4周的有效率明显高于对照组，在第6周末有效率二者无显著性差异；42对照组副作用明显高于研究组。结论无抽搐电休克治疗躁狂发作与利培酮合并碳酸锂治疗具有相同的治疗效果．但无抽搐电休克治疗的起效更快、副反应更少，可作为临床治疗躁狂发作的首选。

Objective To compare Modified Electric Convulsive Therapy （MECT） and Risperidnne merger Lithium carbonate in the treatment of manic episodes of safety and efficacy. Methods From March 2010 to March 2012 and met in the hospital CCMD-3 diagnosis standard each manic episodes of patients with 81 cases were randomly divided into two groups, the team of the patients in the 10 times MECT after treatment with Lithium carbonate maintenance treatment, the control group, with a Lithium carbonate and Risperidone combination therapy, continuous observation six weeks, application the Bech-Rafaelsen Mania Rating Scale （BRMS） and the treatment emergent symptoms scale （TESS） evaluation the efficacy and safety. Results The team in the treatment of 1, 2, 4 weeks of efficient obviously higher than those in the control group, and in the sixth over the weekend of efficient both does not have significant difference; But the side effects of the control group was significantly higher than the research team. Conclusion MECT treatment manic episodes and Risperidone merger Lithium carbonate treatment has the same treatment effect, but MECT has the effect to fast, the advantages of less side effects, and can be used for clinical treatment manic episodes of choice.