2型糖尿病患者糖化血红蛋白与血脂血糖间的关系研究

The Research on the Relationship Between the Patients with Type 2 Diabetes HbA1c and Blood Fat and Blood Sugar

目的探讨2型糖尿病患者糖化血红蛋白水平与血脂、血糖之间的关系。方法采集来我院健康体检的2型糖尿病患者及健康人体检资料各200例,统计其糖化血红蛋白(HbA1c)、空腹血糖(FBG)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)及低密度脂蛋白(LDL-C)等各项指标,对两组的检测结果进行比较,分析糖化血红蛋白与各项检测结果是否具有相关性。结果 2型糖尿病组的HbA1c、FBG、TG、TC及LDL-C明显高于健康对照组,HDL-C则低于健康对照组,两组比较有统计学意义(P<0.05)。糖尿病组HbA1c与TC,LDL-C,HDL-C的关系不明显。结论 2型糖尿病患者血脂异常的发生率显著高于正常人,其血中HbA1c与FBG、TG存在正相关关系,与TC,HDL-C、LDL-C关系不明显。HbA1c、血糖和血脂联合检测对糖尿病及其并发症的早期发现和治疗有着重要意义。

Objective To analyze the relationship between haemoglobin Alc （HbA1c） and lipid profiles, blood glucose in patients with type 2 diabetes mellitus （T2DM）.Methods In 200 T2DM patients and 200 healthy adults who participate in a medical check-up program, analysis of the association bewteen HbA1c and other medical measurements including I-lbA1c, FBG, TG, TC, HDL-C and LDL-C was performed. Results The level of HbA1c, HDL-C,TG, TC and LDL-C were higher in T2DM patients than in healthy adults（P〈0.05）.But the level of HDL-C was lower（P〈0.05）. The relationship between HbA1c and lipid profiles（TC,LDL-C, HDL-C）was not certain in T2DM Patients. Conclusion The prevalence rate of abnormal lipid profiles was higher in T2DM patients than in healthy adults. The level of HbA1c was positively correlated with the level of FBG and TG. The relationship between HbA1c and lipid profiles（TC, LDL-C, HDL-C） was not certain. An overall check-up program of HbA1c, lipid profiles and blood glucose has an important application value in the early diagnosis and therapy of diabetes mellitus.