乌司他丁在重症肺炎集束化治疗中的应用

Ulinastatin in Severe Pneumonia Bundle

目的观察乌司他丁对重症肺炎患者氧合指数和病死率的影响。方法将我院RICU收住的49例重症肺炎患者随机分为乌司他丁治疗组和对照组。均采用集束化治疗,治疗组早期使用乌司他丁,并使用7d以上。观察治疗前后两组氧和指数(PO2/FiO2)变化和病死率等。结果治疗组临床症状改善,PO2/FiO2在治疗后有明显好转(P=0.027);治疗组病死率为25%,对照组为32%(P=0.024)。结论在重症肺炎集束化治疗中早期应用乌司他丁,可改善预后。

Objective To study the effects of ulinastatin on severe pneumonia bundled strategies. Methods 49 patients with severe pneumonia were divided into the study group and the control group. Two groups were imptementade of bundle stralegies. The study group were treated additionally by ulinastatin for 7 day. The effect of therapy in the two group was evaluated by assessing oxygenation index（PO2/FiO2） and mortality. Results The clinical manifestations and blood gas analysis data were evidently proved compared with the before. The results were statistically significant（P=-0.027）. And the mortality reduced obviously（P=0.024）.Conclusion It could prevent the patient＇s condition to worsening, and improve prognosis of patients, when we utilize ulinastatin in the bundled strategy to severe pneumonia.