乙型肝炎后肝硬化患者血小板参数的临床分析

Clinical analysis of platelet parameters in patients with hepatitis B cirrhosis

目的观察血小板参数的变化与肝硬化的关系并探讨其临床意义。方法 114例乙型肝炎后肝硬化患者分为合并上消化道出血组54例,无消化道出血组60例,另选择50例健康者作为健康对照组,将两组血小板参数进行对照比较。结果肝硬化患者血小板计数(PLT)和血小板比容(PCT)分别为(71.95±55.35)×109/L、0.08%±0.07%,与健康对照组比较,均显著降低(P<0.01),平均血小板体积(MPV)和血小板分布宽度(PDW)分别为(12.06±1.23)fL、15.92%±3.33%,比健康对照组显著升高(P<0.01);肝硬化合并上消化道出血组PLT、PCT、MPV、PDW均比无消化道出血组显著降低(P<0.05)。结论血小板参数的测定对评估肝硬化患者肝功能损害程度,判断有无出血倾向具有重要的指导意义。

Objective To observe relationship of the changes of platelet parameters with f hepatic cirrhosis,and to investigate its clinical significance.Methods 114 cases of patients with hepatitis B cirrhosis were divided into complicated with upper gastrointestinal bleeding group（54 cases）,no gastrointestinal bleeding group（60 cases）,another 50 healthy persons were as control group,platelet parameters（PLT,PDW,PCT,MPV） the two groups were compared.Results Compared with the control group,PLT and PCT in patients with hepatic cirrhosis were（71.95±55.35）×109/L,0.08%±0.07%,these were significantly reduced（P〈0.01）.MPV,PDW were（12.06±1.23）fL,15.92%±3.33%,these increased significantly（P〈0.01）.PLT,PCT,MPV,PDW of hepatic cirrhosis complicated by hemorrhage of digestive tract group decreased significantly compared with no gastrointestinal bleeding group（P〈0.05）.Conclusion Determination of the platelet parameters in patients with liver cirrhosis can has important guiding significance in liver function damage assessment and judgement of bleeding tendency.