摘要
目的分析测定白细胞介素18(IL-18)与2型糖尿病(T2DM)关系,探讨2型糖尿病的发病机制。方法对296例T2DM患者及312例健康对照组,应用酶联免疫吸附试验(ELISA)测定两组人群的血清IL-18水平,并进行对比分析。结果 296例T2DM组血清IL-18平均浓度[(298.48±140.38)ng/L]高于312例健康对照组IL-18平均浓度[(236.98±96.01)ng/L],两者之间差异有统计学意义(P<0.05)。结论 IL-18浓度水平可能会影响T2DM易感;T2DM可能与IL-18中某位点上的基因有一定的关系,研究IL-18中某等位基因对T2DM的易感有重要意义。
Objective To explore pathogenesis of type 2 diabetes through analyzing relationship of interleukin 18（Interleukin 18,IL-18）with type 2 diabetes（T2DM）.Methods 296 cases with type 2 diabetes（T2DM） and the control group（312 cases） were selected in this study.Enzyme-linked immunosorbent assay（ELISA） was used to detect the serum IL-18 level in two groups.Results There had significant difference between two groups（P〈0.05）.The serum IL-18 average concentration of 296 cases in type 2 diabetes（T2DM） group（297.38±142.29pg/ml） was higher than that in 312 cases of normal control group（237.53±96.01pg/ml）.Conclusion The concentration of IL-18 may affect the susceptibility to high-risk T2DM.T2DM may be related to the gene at a certain point of IL-18.Study of IL-18 has an important significance on the susceptibility to T2DM.
出处
《检验医学与临床》
CAS
2012年第17期2165-2166,共2页
Laboratory Medicine and Clinic
