4-烯丙氧基-2,2,6,6-四甲基哌啶的合成研究

Study on Synthesis of 4-allyloxy-2,2,6,6-tetramethylpiperidine

以2,2,6,6-四甲基-4-羟基哌啶、烯丙基氯和氢氧化钠为原料催化合成4-烯丙氧基-2,2,6,6-四甲基哌啶,分别研究了反应时间、原料配比、溶剂用量和催化剂用量等条件对合成4-烯丙氧基-2,2,6,6-四甲基哌啶反应的影响,确定的最佳操作条件为：反应温度为45～54℃,反应时间5h,反应物摩尔比为：n（烯丙基氯）∶n（2,2,6,6-四甲基-4-羟基哌啶）∶n（氢氧化钠）为0.45∶0.1∶0.4,溶剂用量为10g,催化剂的用量为0.2g（2,2,6,6-四甲基-4-羟基哌啶为0.1mol）,收率可达到95.43%以上,纯度为99.5%。

The catalyzed synthesis of 4-allyloxy-2,2,6,6-tetramethylpiperidine by the reaction of 2,2,6,6tetramethyl-4-piperidinol, allyl chloride and sodium hydrate was studied.The effect of reaction time, material ratio, the amounts of solvent, and amounts of catalyst on the synthesis were studied, and the proper technological conditions were given as follows： reaction temperature is 45～54℃, reaction time is 5 h,n（allyl chloride）：n （2,2,6,6-tetramethyl-4-piperidinol）：n （sodium hydrate） is 0.45：0.1：0.4, the amounts of solvent is 10 g, the amounts of catalysts is 0.2 g（when 2,2,6,6-tetramethyl-4-piperidinol is 0.1 mol）. The yield of 4-allyloxy2,2,6,6-tetramethylpiperidine can reach 95.43% .Purity of the 4-allyloxy-2,2,6,6-tetramethylpiperidine is 99.0%.