不同剂量阿托伐他汀对冠脉支架植入术患者血脂和C反应蛋白的影响

Effect of different doses of Atorvastatin on coronary stent implantation in patients with serum lipid and C reactive protein

目的:研究探讨不同剂量阿托伐他汀对行冠脉支架植入术(PCI)患者血脂和血清C反应蛋白(CRP)水平的影响。方法:选择我院心内科2009年1～6月收治的64例急性冠脉综合征(ACS)接受PCI治疗的患者,随机平均分为研究组和对照组各32例。在常规治疗基础上,研究组给予阿托伐他汀80mg口服,每日一次;对照组给予阿托伐他汀10mg口服,每日一次。分别于术前1天和术后1周检测血脂和CRP的水平。结果:两组患者术后1周血脂水平较术前1天均有改善(P<0.05),且研究组比对照组改善更明显(P<0.05);两组患者术后1周血清CRP水平较术前1天均降低(P<0.05),且研究组比对照组降低更明显(P<0.05)。结论:两组均可改善血脂水平,同时均可降低ACS患者CRP水平,但是大剂量阿托伐他汀能更好地改善血脂水平和血清CRP水平。

Objective：To explore the effect of different doses of atorvastatin on coronary stent implantation in patients with serum lipid and C reactive protein.Methods：64 patients with acute coronary syndrome（ACS） treated with PCI in our hospital from January 2009 to June 2009 were randomly divided into the study group（n=32） and the control group（n=32）.On the basis of conventional treatment,the study group were given atorvastatin 80mg oral once a day;and the control group were given Atorvastatin 10mg oral once a day.Preoperative day 1 and after 1 week serum lipids and CRP levels were detected.In both group,1 week of blood lipid levels after surgery compared with 1 day before surgery had improvement（P〈0.05）,and the study group improved more significantly than the control group（P〈0.05）;In both group,1 week of serum CRP levels after surgery were lower compared to 1 day before surgery（P〈0.05）,and the study group decreased more significantly than the control group.Conclusion： Two groups can improve lipid levels,can reduce CRP levels of patients with ACS,but large doses of atorvastatin statins can better improve blood lipid levels and serum CRP levels.