胺碘酮联合阿司匹林治疗心房颤动的疗效观察

Curative effect of Amiodarone combined with Aspirin in the treatment of atrial fibrillation

目的:评价胺碘酮联合阿司匹林治疗心房颤动(房颤)的疗效。方法:将57例房颤患者随机分为胺碘酮+阿司匹林组(Ⅰ组,n=28)、洋地黄+阿司匹林组(Ⅱ组,n=29),治疗及随访时间6个月,观察治疗过程中房颤的复发、心律维持及血栓栓塞发生情况。结果:房颤复发Ⅰ组3例(10.7%),Ⅱ组8例(27.6%),Ⅰ组低于Ⅱ组(P<0.05);心室率控制Ⅰ组25例(89.3%),Ⅱ组15例(51.7%),Ⅰ组优于Ⅱ组(P<0.05);血栓栓塞Ⅰ组2例(7.1%),Ⅱ组3例(10.3%),两组差异无统计学意义(P>0.05)。结论:对心功能正常者,胺碘酮联合阿司匹林降低房颤复发及控制心室率方面优于洋地黄联用阿司匹林,但在预防血栓栓塞症的发生方面无明显差异。就目前来看,胺碘酮联用阿司匹林仍是治疗房颤最佳选择。

Objective：To evaluate the effect of Amiodarone combined with Aspirin in the treatment of atrial fibrillation.Methods：57 patients with atrial fibrillation were randomly divided into amiodarone＋aspirin group（group Ⅰ,n=28）and Digitalis＋aspirin group（group Ⅱ,n=29）,treatment and follow up of 6 months.Observed in the course of treatment of atrial fibrillation recurrence,rhythm maintenance and thromboembolism occurs.Results：3 cases of atrial fibrillation recurrence in group Ⅰ,8 cases of atrial fibrillation recurrence in group Ⅱ,group Ⅰ was lower than group Ⅱ（P〈0.05）;25 cases of ventricular rate control in group Ⅰ,15 cases of ventricular rate control in group Ⅱ,group Ⅰ was better than Group Ⅱ（P〈0.05）;2 cases of thromboembolism in group Ⅰ,3 cases of thromboembolism in group Ⅱ,there was no statistical difference（P〉0.05）.Conclusion：For patients with normal cardiac function,Amiodarone combined with Aspirin is better than Digitalis combined with Aspirin on reducing the recurrence of atrial fibrillation and ventricular rate control,but there is no significant difference in the prevention of thromboembolism occurrence.At present,Amiodarone combined with Aspirin is still the best choice.