首次就诊广泛性焦虑障碍患者血浆缩宫素水平研究

The study of oxytocin levels of patients with generalized anxiety disorder

目的:探讨广泛性焦虑障碍患者与正常对照者血浆缩宫素水平差异以及广泛性焦虑障碍患者血浆缩宫素水平与症状严重程度的关系。方法:32～56岁广泛性焦虑障碍患者30例、正常对照30例,分别接受血浆缩宫素水平测定,病例组评定汉密尔顿焦虑量表。结果:非参数检验显示广泛性焦虑障碍患者血浆缩宫素水平高于正常对照组,差异具有统计学意义(213.05±84.60,168.50±88.10;Z=-2.780,P<0.05)。多元回归模型显示,在广泛性焦虑障碍患者中缩宫素水平是影响广泛性焦虑障碍严重程度的因素(校正R2=0.149,F=7.310,P<0.01)。结论:血浆缩宫素水平可能是广泛性焦虑障碍严重程度的影响因素。

Objective：To explore the difference of the oxytocin levels between the patients with generalized anxiety disorder and the normal controls,and the relationship between oxytocin levels and symptom severity.Methods：Thirty 32~56 years old patients with generalized anxiety disorder and thirty normal controls were tested by an enzyme-linked immunosorbent assay to evaluate the oxytocin levels,the patients were tested by HAMA to evaluate the severity of generalized anxiety disorder.Results：Mann-Whitney test showed there were significantly higher oxytocin level in patients compared by the controls,there were statistic difference（213.05±84.60,168.50±88.10;Z=-2.780,P〈0.05）.The multivariate regression model showed that oxytocin levels are generalized anxiety disorder severity influence factors（adjusted R2=0.149,F=7.310,P〈0.01）.Conclusion：Oxytocin levels may be generalized anxiety disorder severity influence factors.