利培酮与阿立哌唑治疗首发精神分裂症的临床疗效及对血糖、血脂的影响

Efficacy of Risperidone and Aripiprazole in first-episode schizophrenia and effects on blood glucose and lipid

目的:观察利培酮和阿立哌唑治疗首发精神分裂症的临床疗效以及对血糖、血脂的影响。方法:将78例首发精神分裂症患者随机分为利培酮组38例和阿立哌唑组40例,治疗8周。均采用阴性和阳性症状量表评定临床疗效,副反应量表评定不良反应,并测定空腹血糖、总胆固醇、甘油三酯的变化。结果:两组临床疗效、阳性和阴性症状量表评分差异无显著性(P﹥0.05);阿立哌唑组副反应量表评分明显低于利培酮组(P<0.01);利培酮组总胆固醇、甘油三酯水平较治疗前明显增高(P<0.01),阿立哌唑组治疗前后比较差异无显著性(P>0.05)。结论:利培酮与阿立哌唑治疗首发精神分裂症疗效相当,阿立哌唑不良反应以及对血糖、血脂的影响小于利培酮。

Objective：To observe the efficacy of Risperidone and Aripiprazole in first-episode schizophrenia and effects on blood glucose and lipid.Methods：Seventy-eight first-episode schizophrenia patients were randomly assigned to Risperidone group（n=38） and Aripiprazole group（n=40）,treated for 8 weeks.Efficacies were assessed with the Positive and Negative Syndrome Scale（PANSS）,adverse reactions with the Treatment Emergent Symptom Scale（TESS） and changes of fasting glucose（Glu）,total cholesterol（TC） and triacylglycerol（TG） detected.Results：There were no significant differences in the PANSS scores（P〉0.05）;the score of the TESS in Risperidone group was significantly lower than that in Aripiprazole group（P〈0.01）;TC and TG levels heightened notably after treatment compared with pre-treatment in Risperidone group（P〈0.01）,and there were no significant differences between pre-treatment and post-treatment in Aripiprazole group（P〉0.05）.Conclusion：Risperidone and Aripiprazole have equivalent efficacy in first-episode schizophrenia,but Risperidone has an advantage in adverse reactions,blood glucose and lipid over Aripiprazole.