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提高抗抑郁治疗临床有效率策略的药理学研究进展

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摘要 临床有效率是指药物治疗的效果与耐受性之间的平衡状态,意味着患者的总体生命质量与功能的改善以及对治疗满意度的提高。临床有效率是抗抑郁药长期治疗以及预防复发治疗所关注的重点。目前研究显示,提高临床有效率的方式为在提高现有药物的疗效以及开发新的不同作用靶点及机制的新型抗抑郁药。本文就上述两种方式近三年的研究文献进行综述,综合文献信息提示,某些现有药物治疗增效策略可以提高临床有效率,
机构地区 天津安宁医院
出处 《中国民康医学》 2012年第16期2018-2020,共3页 Medical Journal of Chinese People’s Health
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参考文献9

  • 1Kasper S,Hajak G,Wulff K,et al.Efficacy of the novel antide-pressant agomelatine on the circadian restactivity cycle and de-pressive and anxiety symptoms in patients with major depressivedisorder:a randomized,double-blind comparison with sertraline[J].J Clin Psychiatry,2010,71(2):109-120.
  • 2Holsboer F,Ising M.Central CRH system in depression and anxie-ty evidence from clinical studies with CRH1 receptor antagonists[J].Eur J Pharmacol,2008,583:350-357.
  • 3Kennedy S H,Rizvi SJ,Agomelatine in the treatment of major de-pressive disorder:potential for clinical effectiveness[J].CNSDrugs,2010,24(6):479-499.
  • 4Cipriani A,Furukawa TA,Salanti G,et al.Comparative efficacy andacceptability of 12 new-generation antidepr essants:a multiple-treat-ments meta-analysis[J].Lancet,2009,373:746-758.
  • 5Blier P,Ward HE,Tremblay P,et al.Combination of antidepressantmedications from treatment initiation for major depressive disorder:a double-blind randomized study[J].Am J Psychiatry,2010,167(3):281-288.
  • 6O’Brien SM,Scully P,Fitzgerald P,et al.Plasma cytokine profiles in depressed patients who fail to respond to selective seroto-nin reuptake inhibitor therapy[J].J Psychiatr Res,2007,41:326-331.
  • 7Preskorn SH,Baker B,Kolluri S,et al.An innovative design to es-tablish proof of concept of the antidepressant ef fec ts o f t heNR2B subu nit selective N-methyl-D-aspartate antagonist,CP-101,606,in patients with treatment-refractory major de-pressivedisorder[J].J Clin Psychopharmacol,2008,28(6):631-637.
  • 8Kornstein SG,Li D,Mao Y,et al.Escitalopram versus SNRI anti-depressants in the acute treatment of major depressive disorder:integrative analysis of four double-blind,randomized clinical tri-als[J].CNS Spectr,2009,14(6):326-333.
  • 9Anderson IM.Selective serotonin reuptake inhibitors versus tricyclicantidepressants:a meta-analysis of efficacy and tolerability[J].JAffect Disord,2000,58:19-36.

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