去氢紫堇碱的结构

Structure of dehydrocorydaline

为了寻找荩草中的生物碱类成分,先用柱层析对其乙醇提取物进行分离,从中得到一个白色粉末,利用颜色反应、紫外光谱、红外光谱、质谱以及氢(1)与碳(13)核磁共振以及二维核磁共振技术无畸变极化转移增强-135,杂核多键相关和杂核单键相关确定了该目标化合物为抑制乙酰胆碱酯酶作用的去氢紫堇碱;该化合物为从该植物中分离得到,而且通过二维核磁共振对其结构进行了论证.

In order to find the active alkaloid of Arthraxon hispidus,a white powder was isolated and purified from alcohol part by column chromatography and it was dehydrocorydaline,as an acetylcholinesterase inhibitor,which was characterized by chromogenic reaction,ultravioet,infrared,mass spectrometry,1H and 13C nuclear magnetic resonance and 2 D nuclear magnetic resonance experiments such as Distortionless Enhanced by Polarization Transfer,Heteronuclear Muliple Boan Correlation and Heteronuclear Single Boan Correlation.The compound is isolated from this plant for the first time and its structure is demonstrated by 2 D NMR experiments.