左卡尼汀与2型糖尿病

Effects of L--carnitine and type 2 diabetes mellitus

目前2型糖屎病被认为是一种进展性疾病。2型糖尿病患者的非药物治疗是以医学营养疗法和加强体力活动为基础的。如果通过加入药物的膳食补充能有效地增强机体胰岛素的敏感性（如LC），那么这对于辅助治疗糖尿病来说是一种非常诱人的新方法。基于上述的研究结果，推测LC补充会减少脂毒性物质的代谢，从而改善线粒体功能和胰岛素信号转导。下一步，需要进行更大规模的临床随机对照实验及基础研究，使得我们能深入的了解，供过于求的脂质通过何种机制导致骨骼肌胰岛素抵抗，以及LC补充如何改变脂肪酸代谢、胰岛素作用和线粒体功能。

Current type 2 diabetes is considered to be a progressive disease. Type 2 diabetes mellitus patients with non drug treatment is to strengthen the medical nutrition therapy and physical activity based. If by adding drug dietary supplements can effectively enhance the insulin sensitivity （ such as LC ）, then for the adjuvant treatment of diabetes is a very attractive new method. Based on the above results, suggesting that LC supplement will reduce lipotoxicity sub stance metabolism, thereby improving mitochondrial function and insulin signal transduction. The next step, need to undertake more large--scale randomized controlled experiment and basic research, we can make in--depth understanding, pile up in excess of requirement lipid mechanism through which leads to insulin resistance in skeletal muscle, as well as LC how changes in fatty acid metabolism, insulin action and mitoehondrial function.