药物治疗对大面积烧伤患者炎性介质和凝血功能的影响

Drug therapy on the treatment of large area burn patients with inflammatory mediators and coagulation effect

目的：药物治疗对大面积烧伤患者炎性介质和凝血功能的影响。方法：32例大面积烧伤患者治疗前后都进行白介素-10（IL-10）、白介素-8（IL-8）、血小板计数（PIT）、凝血酶原时间（PT）、凝血酶时间（TT）检测。结果：治疗前静脉血中IL-8、IL-10浓度明显高于治疗后。均有统计学意义（P〈10．05）。治疗后PLT明显高于治疗前（P〈O．05），治疗后PT和TT较治疗前显著缩短（P〈0．05）。结论：大面积烧伤患者炎性介质和凝血异常的机制复杂，合理的药物治疗能缓解相关指标的变化，从而为改善患者生理功能提供保障。

Objective： drug therapy on the treatment of large area burn patients with inflammatory mediators and coagulation effect. Methods： 32 cases of large area burn patients before and after treatment of interleukin -10 （ IL-10 ）, interleukin -8 （ IL-8 ）, platelet count （ PIT ）, prothrombin time （ PT ）, thrombin time （ TT ） detection. Results： before treatment in venous blood IL-8, IL-10 concentration was significantly higher after treatment. There were statistical significance （ P〈0.05 ）. After treatment of PLT were obviously higher than those before treatment （ P〈0.05 ）, PT and TT after treatment than be- fore treatment was significantly shortened （ P〈0.05 ）. Conclusion： Patients with large area of burn of inflammatory mediators and coagulation abnormalities in the mechanisms of complex, rational drug therapy can relieve the related index changes, so as to improve the physiological functions of patients to provide protec- tion.